Changes in sex drive, energy, erections or strength can leave you feeling unlike yourself. A testosterone test and clinical review can help establish whether hormones are part of the picture.
Heracles brings specialist expertise to that next step, with testosterone testing and a review of your symptoms and health history. Check your testosterone.
Low testosterone, also called testosterone deficiency or male hypogonadism, means the testes are not producing enough testosterone for normal function because of a problem in the testes themselves, the hormonal signals controlling them, or a potentially reversible suppression caused by illness or another condition.
The more specific symptoms include reduced sexual desire, fewer spontaneous or morning erections and, in more severe cases, loss of body hair, hot flushes, small testes or reduced bone density. Fatigue, low mood, poor concentration, weight gain and reduced gym performance can occur, but they have many other explanations.
UK and European guidance supports testing symptomatic men with a morning, fasting total testosterone measurement and confirming a low result on a separate day. The result must then be interpreted with the symptoms, the laboratory method, sex hormone-binding globulin and other hormones where relevant. One result, an online questionnaire or symptoms alone is not enough.
Testosterone is an androgen hormone produced mainly by the testes under the control of the hypothalamus and pituitary gland in the brain. The hypothalamus releases gonadotrophin-releasing hormone. This signals the pituitary to release luteinising hormone and follicle-stimulating hormone. Luteinising hormone stimulates testosterone production; follicle-stimulating hormone and high local testosterone concentrations inside the testes support sperm production.
This hormonal circuit is often called the hypothalamic-pituitary-gonadal axis. It regulates:
Sexual symptoms are generally more informative than fatigue alone. They can include:
Erectile dysfunction does not automatically mean low testosterone. Blood-vessel disease, diabetes, medicines, smoking, anxiety, relationship factors and pelvic conditions are common alternatives. A man can also have both testosterone deficiency and another cause of erectile dysfunction.
Possible physical features include:
Men may report:
A health questionnaire helps your clinician understand what has changed. Diagnosis also requires correctly timed blood tests and review of other possible causes. At Heracles, your assessment and results are considered together.
Clinicians divide the causes into primary, secondary and functional hypogonadism. The distinction guides further tests and changes the treatment conversation.
In primary hypogonadism, the testes cannot respond adequately even though the pituitary is sending a strong signal. Testosterone is low and luteinising hormone is usually raised. Follicle-stimulating hormone may also be raised, particularly when sperm production is affected.
Possible causes include:
In secondary hypogonadism, the hypothalamus or pituitary does not send an adequate signal to the testes. Testosterone is low while luteinising hormone and follicle-stimulating hormone are low or inappropriately normal.
Causes can include:
A very low testosterone result with a secondary pattern, a raised prolactin result, visual symptoms, a new severe headache or evidence of other pituitary-hormone problems may justify specialist investigation and sometimes pituitary imaging. It should not be managed as a routine lifestyle problem.
The hormonal axis can be suppressed without a fixed structural abnormality. This is often called functional hypogonadism. Associations include:
“Functional” does not mean imaginary or harmless. It means that improving the underlying condition may improve testosterone and wider health, sometimes without testosterone replacement. The appropriate plan depends on the cause, severity, symptoms and fertility goals.
Testosterone often declines gradually with age, while sex hormone-binding globulin may rise and reduce the proportion available to tissues. But ageing alone does not establish hypogonadism, and the popular phrase “male menopause” can be misleading. Men do not usually experience the abrupt universal hormonal change seen at menopause.
Late-onset hypogonadism is a clinical diagnosis: compatible symptoms plus consistently low testosterone after other contributors have been considered. TRT is not a general anti-ageing treatment for men with normal testosterone.
The clinician should ask about sexual function, spontaneous erections, fertility plans, puberty, testicular history, prescription medicines, opioids, anabolic-steroid exposure, alcohol, sleep, weight change, training load, energy intake and chronic illness. Mood, thyroid symptoms, anaemia and sleep apnoea may also need attention.
The examination will depend on the history. It may include body composition, blood pressure, body hair, breast tissue, testes and signs of pituitary, metabolic or systemic disease.
The Society for Endocrinology and Association for Laboratory Medicine recommend morning, fasting testing when the man is not acutely ill. Measurements taken later than 11am, after eating or during acute illness should not be used to diagnose male hypogonadism under that position statement. Shift workers need individual advice because clock time may not reflect their biological morning.
A low result must be repeated on a separate day. Testosterone varies within a person, so the second measurement protects against diagnosing a temporary dip as a persistent deficiency.
The UK joint position statement gives a practical framework for morning, fasting results in symptomatic men:
| Total testosterone | General interpretation |
|---|---|
| Below 8 nmol/L on two tests | Hypogonadism is likely, subject to clinical assessment and investigation |
| 8–12 nmol/L | Borderline zone requiring careful clinical correlation and, where indicated, SHBG and calculated free testosterone |
| Above 12 nmol/L | Not usually consistent with hypogonadism; one correctly collected result above this level will usually exclude it |
Depending on the result and history, further tests may include:
The findings from the first assessment should determine which further tests are needed.
The overlap is substantial:
| Symptom | Other explanations that may need consideration |
|---|---|
| Fatigue or brain fog | Poor sleep, sleep apnoea, anaemia, thyroid disease, depression, infection, medication effects, under-fuelling |
| Low libido | Stress, depression, relationship factors, medicines, high prolactin, thyroid disease, sexual pain or dysfunction |
| Erectile difficulty | Vascular disease, diabetes, smoking, alcohol, medication effects, anxiety, pelvic or neurological disease |
| Reduced strength | Training programme, inadequate protein or energy, injury, neurological or muscular disease, ageing |
| Weight gain | Energy balance, sleep, alcohol, medicines, thyroid disease, metabolic illness |
| Low mood | Depression, anxiety, burnout, bereavement, sleep loss, substance use, other health conditions |
They can improve testosterone when a reversible suppressor is present. Clinically useful changes may include treating sleep apnoea, reducing excess weight without crash dieting, improving diabetes control, reducing harmful alcohol use, correcting under-fuelling, allowing adequate recovery and reviewing medicines with the prescriber.
The size of any change varies, and lifestyle advice should not become a reason to delay investigation of marked deficiency, testicular failure or pituitary disease. Supplements marketed as “test boosters” are not substitutes for diagnosis; their ingredients, evidence and safety vary.
TRT may be considered when a man has consistent symptoms, confirmed biochemical deficiency, a cause for which replacement is appropriate, and no contraindication that makes treatment unsuitable. The goal is to restore testosterone to a physiological range and improve relevant symptoms, not to create supraphysiological levels or enhance performance in a man without hypogonadism.
Fertility must be discussed before treatment. Exogenous testosterone suppresses luteinising hormone, follicle-stimulating hormone and sperm production. It is not a contraceptive, but it can substantially reduce fertility and is contraindicated in men actively seeking fertility under European guidance. Alternative specialist approaches may be more appropriate in selected men with secondary hypogonadism.
Arrange prompt assessment rather than relying on a commercial hormone test if symptoms are accompanied by:
Chest pain, severe breathlessness, sudden neurological symptoms or an acute mental-health crisis require urgent care through the appropriate emergency service.
Start with your symptoms and a properly timed testosterone test. Your clinician reviews the result, arranges repeat or further testing where needed and explains your care options. Tell them about medicines, previous hormone use and plans for children.
Heracles was co-founded by Professor Suks Minhas and Professor Tet Yap. Our team brings together expertise in urology, andrology, endocrinology, nutrition and sexual health. Meet the specialists behind your care.
Check your testosterone with Heracles.
No. Treatment depends on the cause, severity, symptoms, reversibility, fertility plans and safety. Some men need treatment of an underlying condition; others may need specialist hormone or fertility care.
An at-home test may be a convenient first measurement if the sample method, laboratory and collection conditions are appropriate. Whether it is sufficient for diagnosis depends on the clinical pathway. A low or unexpected result should be confirmed and interpreted by a clinician rather than used to self-start treatment.
TRT uses prescribed testosterone to restore physiological levels in confirmed hypogonadism. Non-medical anabolic-steroid use aims for different effects, often at supraphysiological exposure, and can suppress natural testosterone and fertility.
